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Researchers produce high yield of IgG in bird eggs.(Brief Article)
2002 SEP 25 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A standardized method was developed to produce easily-purified antivenom in chicken eggs, according to researchers in India.
"The therapeutic use of specific antibodies is invaluable in certain clinical conditions, such as administration of specific antivenom for snakebite envenomation," said C. Maya Devi and colleagues at the Sree Chitra Tirunal Institute for Medical Sciences and Technology in India.
The production of antivenom is usually accomplished by inoculating a mammal with the specific venom antigen and isolating the resulting IgG antibodies from the serum. Antibody yields are often low and extraneous immunogenic materials not removed by purification can produce strong, undesirable immune reactions.
The method developed by Devi and associates involves production of antibodies in a bird's egg. Purification of the antigen-specific IgG is accomplished through lipid removal and gel filtration. The researchers claim 80-100 mg of purified IgG can be produced from a single egg (Development of viper-venom antibodies in chicken egg yolk and assay of their antigen binding capacity. Toxicon, 2002;40(7):857-861).
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Source: HighBeam Research, Researchers produce high yield of IgG in bird eggs.(Brief Article)