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Antibiotic-resistant Streptococcus pneumoniae increasing in Belgium.(Brief Article)
2002 SEP 25 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A study done in Belgium to characterize bacteremic Streptococcus pneumoniae isolates from children and elderly adults revealed significant differences between the two and detected a dramatic increase in antibiotic resistance.
Johan Flamaing and colleagues at University Hospital Leuven in Belgium characterized 5837 blood isolates collected from 1994-2000 in patients with Streptococcus pneumoniae bacteremia. Of the total, 843 (14%) of the isolates were from children 4 years old and younger and 3144 (54%) were from adults 60 years old or older.
Significantly more S. pneumoniae serogroups/serotypes (SGTs) occurred in the elderly patients (36) than in the children (26; p=0.03). Children were significantly more likely than elderly adults to be infected with SGTs 6, 14, 18, and 19. In contrast, SGTs 3, 7, 8, 9, 11, 12, 15, 20, 22, and 35 were significantly more likely to cause bacteremia in the elderly than in the young.
The rate of penicillin-resistant isolates (MICgreater than or equal to0.1 mg/L) increased significantly in children (8.2% to 18.9%, p=0.03) and the elderly adults (5.5% to 16.35%, p=0.001) over the 7-year period. Erythromycin resistance (MICgreater than or equal to1 mg/L) also increased significantly in the isolates obtained from the elderly adults (18.6% to 33.65%, p=0.001), but was still more prevalent in the isolates obtained from children (25.7% vs. 44.7%, respectively, p=0.001).
Children would receive more complete protection from the 7, 9, and 11 valent vaccines than the elderly adults would (82% vs. 55.5%, 89.5% vs. 65%, and 92% vs. 77.5%, respectively; p=0.001). However, theoretically, the 23 valent ...
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Source: HighBeam Research, Antibiotic-resistant Streptococcus pneumoniae increasing in...