AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
A recombinant vaccinia virus Lister shows promise as a vaccine vector.(Brief Article)
2002 SEP 18 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A defective vaccinia virus Lister strain is a safe and effective virus vector, according to investigators in Austria.
"Potent and safe vaccinia virus vectors inducing cell-mediated immunity are needed for clinical use," commented B. T. Ober and colleagues at Baxter BioScience/Vaccine AG in Austria. "Replicating vaccinia viruses generally induce strong cell-mediated immunity; however, they may have severe adverse effects. As a vector for clinical use, we assessed the defective vaccinia virus system, in which deletion of an essential gene blocks viral replication, resulting in an infectious virus that does not multiply in the host."
The investigators compared the activity of the vaccinia virus Lister, with and without an inserted human p53 gene, with that of the recombinant vaccinia virus Ankara (MVA), currently considered the "gold standard" of vaccinia virus vectors.
The cellular and humoral immune responses generated by the defective vaccinia virus Lister were comparable with the MVA-induced responses. Cell culture studies and experiments in immunodeficient SCID mice confirmed the safety of the defective viruses by demonstrating they were tolerated at levels 10,000 times greater than were the wild-type Lister viruses.
An extra measure of safety is provided by the ability to produce the defective vaccinia viruses in an ...
- A recombinant vaccinia virus Lister shows promise as a vaccine vector.
- Newspaper article from: Biotech Week September 18, 2002 700+ words
...medical writer - A defective vaccinia virus Lister strain is a safe and effective...compared the activity of the vaccinia virus Lister, with and without an inserted...generated by the defective vaccinia virus Lister were comparable with the...
- Accidental infection of laboratory worker with vaccinia virus. (Dispatches).
- Magazine article from: Emerging Infectious Diseases Moussatche, Nissin Tuyama, Mari Kato, Sayuri E.M. Castro, Ana Paula V. Njaine, Brian Peralta, Regina H. Peralta, Jose M. Damaso, Clarissa R.A. Barroso, Paulo F. June 1, 2003 700+ words
...inoculation of a laboratory worker with vaccinia virus. Although the patient had previously...virus recovered from the lesions. The vaccinia virus--specific immunoglobulin G levels...smallpox vaccine, formulated with vaccinia virus, is a highly effective immunizing...
- Mutant Vaccinia Virus Attacks Tumor Targets, Ignores Resting Cells.(Brief...
- Newspaper article from: Virus Weekly January 29, 2002 700+ words
...have enhanced the tumor specificity of vaccinia virus in order to increase its effectiveness...The resulting construct, a mutant vaccinia virus devoid of thymidine kinase (TK[superscript...creating a double-deleted mutant vaccinia virus (vvDD-GFP)." When McCart and...
- Mutant Vaccinia Virus Attacks Tumor Targets, Ignores Resting Cells.
- Newspaper article from: Gene Therapy Weekly January 31, 2002 700+ words
...have enhanced the tumor specificity of vaccinia virus in order to increase its effectiveness...The resulting construct, a mutant vaccinia virus devoid of thymidine kinase (TK[superscript...creating a double-deleted mutant vaccinia virus (vvDD-GFP)." When McCart and...
- Lack of transmission of vaccinia virus.(Letter to the editor)
- Magazine article from: Emerging Infectious Diseases Stark, James H. Frey, Sharon E. Blum, Paul S. Monath, Thomas P. April 1, 2006 700+ words
...spread of the live attenuated vaccinia virus is considered the predominant...have measured the presence of vaccinia virus on the dressings or hands...however, the recovery of vaccinia virus in the environment has not...
- Construction of a Vaccinia Virus Vectored Multiepitope Live Vaccine for...
- Newspaper article from: Vaccine Weekly March 15, 1999 700+ words
Malaria Vaccines "Construction of a Vaccinia Virus Vectored Multiepitope Live Vaccine for Plasmodium...attractive approach for the purpose of above is the vaccinia virus vector. Because vaccinia virus is administered as a live virus, it has the...
- Vaccinia virus encodes previously uncharacterized inhibitor of apoptosis.
- Newspaper article from: Drug Week January 30, 2004 700+ words
...com & NewsRx.net) -- The vaccinia virus encodes a previously uncharacterized...that function at the mitochondria. Vaccinia virus, the prototypic member of the Poxviridae...previously unidentified protein in vaccinia virus, is responsible for the inhibition...
- Membrane proteins of virions protects against vaccinia virus.
- Newspaper article from: Drug Week December 3, 2004 700+ words
...induced protective immunity to vaccinia virus. "Infectious intracellular and extracellular forms of vaccinia virus have different outer membrane proteins...percutaneous immunization with live vaccinia virus," stated Christiana Fogg and...