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Vaccine effective in mice with cell-mediated immune function.(Brief Article)
2002 SEP 18 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A vaccine against the Ebola Zaire virus (EBO-Z) is effective in mice with cell-mediated immune function although its efficacy in other animals is questionable, researchers in Maryland say.
"It is thought that a vaccine against EBO-Z may have to induce both humoral and cell-mediated immune responses to successfully confer protection," explained Mangala Rao and colleagues at the Walter Reed Army Institute of Research in Silver Spring and the U.S. Army Medical Research Institute of Infectious Diseases in Frederick.
Rao and coauthors found evidence confirming this hypothesis, according to their study published in the September issue of the Journal of Virology.
They tested a liposome-encapsulated irradiated EBO-Z vaccine [L(EV)] containing all of the proteins produced by wild-type EBO-Z. All of the 94 mice inoculated with L(EV) survived EBO-Z challenge with no ill effects, they reported.
However, mice pretreated with anti-CD4 antibodies gained no protection from the L(EV) vaccine. This experiment showed that functioning CD4 T cells are needed for this vaccine to work, the researchers noted.
Unfortunately, L(EV) tests on primates returned less promising results than those seen in the murine model (Induction ...
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