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Reactive nitrogen species foster vascularity of breast tumors.(Brief Article)
2002 SEP 19 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - A marker for protein conversion has been used to detect reactive nitrogen species at the edges of breast cancer tumors. These nitric oxide derivatives may interact with inflammatory cells to modulate tumor vascularity, researchers now believe.
A report in Breast Cancer Research and Treatment suggests nitrotyrosine (NO2Y) can be detected in cells at the margins of breast cancer tumors containing greater vessel density.
"Nitrotyrosine is a global marker of protein modification by reactive nitrogen species such as peroxynitrite derived from nitric oxide," described M. Samoszuk and colleagues, investigators at the University of California - Irvine, Irvine Medical Center in Orange, California.
Samozuk's group tested 30 breast cancer specimens for NO2Y levels. Though NO2Y levels were usually low, the samples with the highest levels of NO2Y also contained the greatest number of tumor vessels (Association between nitrotyrosine levels and microvascular density in human breast cancer. Breast Cancer Res Treat, August 2002;74(3):271-278).
Tissue staining demonstrated NO2Y primarily in inflammatory cells that were ...
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