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Two new HRT reviews support findings of recently halted clinical trial.(hormone replacement therapy)(Brief Article)
2002 SEP 19 - (NewsRx.com & NewsRx.net) -- Two new systematic reviews of a broad spectrum of research on hormone replacement therapy (HRT) to prevent cardiovascular disease and other long-term health problems support the findings of a recently halted clinical trial in the Women's Health Initiative (WHI).
These reviews were developed for the U.S. Preventive Services Task Force as background for new recommendations on HRT use that will be published in the fall for clinicians and patients.
The two reviews, one in the August 20, 2002, Annals of Internal Medicine and the other in the August 21 Journal of the American Medical Association, found that for women taking HRT for 5 years or longer to prevent chronic conditions, harms could exceed benefits. The reviews were not able to determine whether the harms or benefits depended on type of hormones used.
Although one study of estrogen and progestin in the WHI was stopped after 5 years because harms exceeded benefits, a second study of estrogen alone for women who have had a hysterectomy is continuing because the balance of benefits and harms is not yet clear.
The Annals article primarily addresses cardiovascular disease, and the JAMA article is an overall summary of the risks and benefits of HRT. The reviews did not examine the use of HRT to treat menopausal symptoms or specific conditions such as osteoporosis.
The JAMA article confirms the benefits of HRT to prevent bone fractures and probably colorectal cancer but found that the effects of HRT on dementia were uncertain. Harms include an increased risk of blood clots and stroke, an increase in breast cancer with 5 or more years of use, and a probable increase in gallbladder disease. New evidence suggests that HRT does not reduce the risk of heart disease and may modestly increase risk.
The reviews were funded by the Agency for Healthcare Research and Quality (AHRQ), which sponsors the Task Force. Data from the WHI trial were incorporated into the Annals and JAMA articles in an effort to integrate those results with systematic reviews of thousands ...
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Source: HighBeam Research, Two new HRT reviews support findings of recently halted clinical...