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Study identifies upregulated enzyme in invasive breast cancers.(lysyl oxidase)
2002 SEP 12 - (NewsRx.com & NewsRx.net) -- by Sonia Bell-Nichols, senior medical writer - Upregulated expression of an extracellular enzyme seems be responsible for the invasiveness of breast cancers. Diminishing its activity at the molecular level could be one way of curbing breast cancer metastasis, researchers suggest.
In earlier studies, Dawn A. Kirschmann and colleagues at the Holden Comprehensive Cancer Center at The University of Iowa in Iowa City found that lysyl oxidase (LOX) expression, responsible for degrading the "glue" that holds cells together, is higher in breast cancers that are invasive than in breast cancers that are not.
A subsequent study has examined LOX at a molecular level in breast cancer and has determined that LOX and its analogs can be contained at both a genetic level and an enzymatic level in metastatic breast cancer cell lines.
Kirschmann's evaluation detected high levels of mRNA expression by LOX and LOX-like (LOXL) enzymes "only in breast cancer cell lines with highly invasive phenotypes."
"LOX and LOXL2 showed the strongest association with invasive potential in both highly invasive/metastatic breast cancer cell lines tested (MDA-MB-231 and Hs578T)," the team said.
Transfection of the two cell lines with antisense oligonucleotides to LOX limited their ability to disseminate into collagen/gelatin matrices. The enzymatic inhibitor beta-aminopropionitrile also incapacitated breast cancer cell invasiveness by ...
- LOX, STOCK AND BARREL.(Business)
- Newspaper article from: The Register-Guard (Eugene, OR) October 5, 2003 700+ words
...in Springfield, salmon smokehouse Oregon Lox Co., is migrating to west Eugene. The...money to take the ownership plunge. Oregon Lox recently spent $265,000 to buy 2.3...18,500 square-foot plant that Oregon Lox has leased since 1991 on Shelley Street...
- NIH, Jackson Laboratory and DuPont Pharmaceuticals Sign Cre-lox(TM) Technology...
- Press release article from: PR Newswire August 20, 1998 700+ words
...the use of DuPont's proprietary Cre-lox technology. The agreements resolve long...have a mutually agreeable means for Cre-lox technology to be used in research conducted...Harbor Laboratory yesterday. The Cre-lox technology involves site-specific recombination...
- Efficient deletion of transgenic DNA from complex integration locus of rice...
- Magazine article from: Crop Science Moore, Sarah K. Srivastava, Vibha March 1, 2006 700+ words
...Ebinuma et al., 1997), with Cre/lox being the most efficient one so far (Andreas...Srivastava, 2005). Phage P1-derived Cre/lox system consists of a 38.5-kDa recombinase...between 34-bp recombination targets called lox sites. Cre-mediated recombination between...
- LOX-1 is a cell-adhesion molecule involved in leukocyte replacement.
- Newspaper article from: Heart Disease Weekly April 13, 2003 700+ words
...NewsRx.com & NewsRx.net) -- LOX-1 is a cell-adhesion molecule involved...low-density lipoprotein receptor-1 (LOX-1) is a major endothelial receptor for...proatherogenic role in atherosclerosis. LOX-1 expression is induced by inflammatory...
- Lox maker finishes new plant.
- Newspaper article from: Register Guard (Eugene, OR) March 2, 2007 700+ words
Byline: Joe Mosley Mar. 2--Oregon Lox Co., a salmon smokehouse that operated...resembles a warehouse, will be where Oregon Lox processes more than a million pounds of salmon per year to make lox and smoked salmon products. Owners James...
- "Whaddaya Mean We Gotta Wear White, 100% Cotton Coveralls During LOX...
- Magazine article from: Flying Safety Vigil, Joe Baker, Mike November 1, 2001 700+ words
...required to be worn--and not worn--during LOX servicing operations. The message generated...Protective Equipment (PPE) For Liquid Oxygen (LOX) Servicing 1. This is a retransmission...wear of body protection when conducting LOX operations nor a test that can be applied...
- Acme Smoked Fish Products, Noah's Lox Shmears Voluntarily Recalled by Noah's...
- Press release article from: Business Wire August 5, 1996 700+ words
...5, 1996--The two Noah's Bagels franchisees today announced a voluntary recall of lox trim sold by the pound, Noah's Lox Shmear, and Noah's Light Lox Shmear after lab tests uncovered low levels of listeria monocytogenes in lox trim supplied...
- Time critical factors in an emergency situation.(LOX Safety)
- Magazine article from: Mech Cintron, Edgar September 22, 2005 700+ words
...squadrons conduct follow-on training for LOX/gaseous oxygen safety precautions and...mishap in which someone gets splashed with LOX. Monitor the Sailors' responses, especially...relief tools. Many people involved in LOX evolutions don't check out these tools...
