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Women with PCOS and their siblings with hormone problems have same gene defect.(polycystic ovary syndrome)
2002 SEP 12 - (NewsRx.com & NewsRx.net) -- Siblings of women with polycystic ovary syndrome (PCOS) have metabolic and hormonal abnormalities that are linked to the same gene defect that causes PCOS, a disorder associated with irregular periods, infertility, excessive body hair and increased risk for diabetes.
These new findings came from the $6 million National Institutes of Health-funded National Centers Program for Infertility Research. The study was led by Northwestern University researcher Andrea Dunaif, MD, Charles F. Kettering Professor, chief of endocrinology and metabolism and professor of medicine at he Feinberg School of Medicine, and collaborators at Pennsylvania State University and the University of Pennsylvania.
Dunaif and coinvestigators believe the location of the PCOS gene mutation is on chromosome 19, near the insulin receptor gene, which plays a key role in allowing insulin to enter cells and metabolize sugar. This marker, called allele 8 of D19S884, was associated with risk factors for diabetes in PCOS women and their brothers.
In recently published studies, approximately 50% of the sisters of PCOS women had elevated androgen (so-called "male hormones" that are present in both men and women) levels while the other half of the sisters were unaffected. Of the high-androgen group, half (or 25% of the sisters) had PCOS and insulin resistance, while the other 25% were insulin resistant but showed ...
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- Magazine article from: Family Practice News JANCIN, BRUCE June 15, 2000 700+ words
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...suffer from polycystic ovary syndrome (PCOS), one of the most common reproductive...women who are at risk for developing CVD. PCOS, which affects 5% to 10% of reproductive...CVD, and metabolic syndrome. Signs of PCOS include hirsutism (hair growth), menstrual...
- Should PCOS be treated with insulin sensitizers or oral...
- Magazine article from: Family Practice News Nestler, John Legro, Richard S. February 1, 2006 700+ words
...Sensitizers Polycystic ovary syndrome (PCOS) is characterized by androgen excess and...chronic use. Most if not all women with PCOS have insulin resistance; indeed, insulin...Studies comparing lean and obese women, with PCOS and without, have shown that lean women...
- Should PCOS be treated with insulin sensitizers or oral...
- Magazine article from: OB GYN News Nestler, John Legro, Richard S. February 15, 2006 700+ words
...Sensitizers Polycystic ovary syndrome (PCOS) is characterized by androgen excess and...chronic use. Most if not all women with PCOS have insulin resistance; indeed, insulin...Studies comparing lean and obese women, with PCOS and without, have shown that lean women...
- Metformin urged for PCOS, despite lack of data: current knowledge of the risks...
- Magazine article from: Family Practice News Kilgore, Christine August 1, 2006 700+ words
...patients with polycystic ovary syndrome (PCOS)--as well as the existence of only...to addressing the immediate symptoms of PCOS, said Dr. John Nestler, professor of...may well be the initiating abnormality in PCOS, and has been shown to normalize or improve...
- Study links PCOS to depression.(News)
- Magazine article from: OB GYN News Dixon, Bruce K. November 15, 2005 700+ words
...women. "We recommend that women with PCOS should be routinely screened and adequately...and Andrology Society. Among women with PCOS, the odds ratio was 5.11 for newly diagnosed...compared with controls who did not have PCOS, said Ms. Hollinrake, who is a third...
- Polycystic Ovary Syndrome (PCOS).
- Magazine article from: Women's Health Activist McCurtis, Kiesha January 1, 2008 700+ words
...UNKNOWN CAUSE, Polycystic Ovary Syndrome (PCOS) is a condition that is frequently misdiagnosed. PCOS is a reproductive endocrine disorder in which...hormones (androgens) such as testosterone. PCOS affects about five percent of U.S. women...
- Study finds PCOS, depression link.(News)(polycystic ovary syndrome )
- Magazine article from: Family Practice News Dixon, Bruce K. November 15, 2005 700+ words
...women. "We recommend that women with PCOS should be routinely screened and adequately...and Andrology Society. Among women with PCOS, the odds ratio was 5.11 for newly diagnosed...compared with controls who did not have PCOS, said Ms. Hollinrake, a third-year...
Source: HighBeam Research, Women with PCOS and their siblings with hormone problems have same...