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Japan's TB revaccination program not cost-effective.(Brief Article)
2002 SEP 11 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Revaccination of Japanese children with bacillus Calmette-Guerin to prevent tuberculosis is not cost-effective, according to an analysis published in Preventive Medicine.
"Bacillus Calmette-Guerin (BCG) revaccination has been implemented in Japan among tuberculin-negative first grade primary and first grade junior high school students for decades," commented Mahbubur Rahman and colleagues at Kyoto University. "Controversies regarding the effectiveness of BCG revaccination and low incidence of tuberculosis (TB) among Japanese children prompted this study."
The analysis was conducted for a cohort of 2.86 million Japanese students (1.35 million attending first grade primary school and 1.51 million attending first grade junior high) who were revaccinated against tuberculosis during 1996 (Is bacillus Calmette-Guerin revaccination necessary for Japanese children? Prev Med, 2002;35(1):70-77).
Assumptions included a revaccination effectiveness rate of 50%, a 10-year protective period, and an annual discount rate of 5%. The investigators incorporated these values into the analysis to calculate the number of tuberculosis cases prevented, the number of vaccinations required to prevent one case of TB, the cost of preventing one case of TB, and the overall benefit-cost ratio,
Over 10 years, the BGC revaccination program in Japan prevents 296 cases of TB. However, the cost of ...
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