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Maternal RSV immunization important to prevent infant infections.(Brief Article)
2002 SEP 11 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Maternal antibodies offer the major form of protection against respiratory syncytial virus (RSV) in infants born in Mozambique.
Anna Roca and colleagues in Spain conducted a case-control study of RSV infection in 62 infants, younger than 12 months, residing in a rural area of Mozambique.
Of the 62 infants, 31 had contracted an RSV infection; the other 31 subjects were controls matched for age and sex with the infected subjects. A membrane fluorescent antibody test (MFAT) was used to detect and quantify anti-RSV immunoglobulin G (IgG) antibodies.
Analysis for neutralizing antibodies also was done. Serum samples from infants in the control group were significantly more likely to contain anti-RSV IgG antibodies and to have higher titers of anti-RSV IgG than infected infants (p
The presence of immunoglobulin A (IgA) antibodies was unusual in both control and infected infants (0/31 vs. 4/31, respectively). IgG is the only type of antibody able to cross the placenta (IgA cannot), therefore this indicates protection was conferred through the mother (Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique. Journal of Medical Virology, August 2002;67(4):616-623).
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