AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Virulent poliovirus causes paralysis in baby.(Brief Article)
2002 SEP 4 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A mutated strain of poliovirus derived from the Sabin vaccine strain caused paralytic poliomyelitis in a baby who possessed a competent immune system.
"Successful implementation of the global poliomyelitis eradication program raises the problem of vaccination against poliomyelitis in the posteradication era," explained Elena A. Cherkasova and her colleagues at Moscow State University and the U.S. Food and Drug Administration in Rockville, Maryland. "One of the options under consideration envisions completely stopping worldwide the use of the Sabin vaccine."
However, Cherkasova and her associates warn that this approach is a safe and effective one only if wide circulation of the vaccine strain does not occur. This assumption has been thrown into doubt by a case of paralytic polio found in a 7-month-old baby who possessed an intact immune system and lived in an area of adequate immunization coverage.
The virulent virus developed from the Sabin vaccine strain and, upon examination, was found to be a double (type 1-type 2-type 1) recombinant (Long-term circulation of vaccine-derived poliovirus that causes paralytic disease. Journal of Virology, 2002;76(13):6791-6799).
"The number of mutations accumulated in both the type 1-derived and type 2-derived portions of the recombinant genome suggests that both had diverged from their vaccine ...
- South Korean Scientist Develops Vaccine Strain for Bird Flu.
- News wire article from: YON - Yonhap News Agency of Korea February 21, 2004 700+ words
...South Korean scientist said Friday he has developed a vaccine strain for the bird flu virus. Professor Suh Sang-hee of Chungnam National University said he will test the vaccine strain for the H5N1 virus on monkeys next month to check its...
- Update: Potential Exposures to Attenuated Vaccine Strain Brucella abortus RB51...
- Magazine article from: MMWR. Morbidity and Mortality Weekly Report Noe, R S; Bower, W A; Diaz, P D; Rotz, L D; Holmes, H T; Resultan, E G January 18, 2008 700+ words
...officials notified CDC of potential exposures to attenuated vaccine strain Brucella abortus RB51 (RB51) in multiple clinical laboratories...of potential bioterrorism agents. RB51 is an attenuated vaccine strain of B. abortus used to vaccinate cattle against brucellosis...
- Only Sabin type 3 polio vaccine strain mutation reduces viral growth.
- Newspaper article from: Immunotherapy Weekly May 5, 2004 700+ words
...the two eIF4G isoforms." Malnou and associates published their study in the Journal of Biological Chemistry (Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context. J Biol...
- Potential Exposure to Attenuated Vaccine Strain Brucella abortus RB51 During a...
- Magazine article from: MMWR. Morbidity and Mortality Weekly Report Anonymous December 21, 2007 700+ words
...laboratorians at a state laboratory from an isolate used in a recent Laboratory Preparedness Survey (LPS). RB51 is an attenuated vaccine strain of B. abortus used to vaccinate cattle against brucellosis; human illness is known to have resulted from RB51 vaccine...
- Meningitis risk after measles-mumps-rubella vaccination varies by vaccine...
- Newspaper article from: Vaccine Weekly March 12, 2003 700+ words
...A case-crossover design has revealed that the risk of meningitis after measles-mumps-rubella vaccination varies by vaccine strain. According to recent research from Korea, "Epidemiologic study of a vaccine's adverse events is not easy; so many...
- CANADIANS USE CHIP IN ATTEMPT TO RESTORE GENES OF ORIGINAL LIVE TB VACCINE...
- Magazine article from: BIOWORLD Today Leff, David N. June 1, 1999 700+ words
Editor's note: Science Scan is a roundup of recently published biotechnology-relevant research. For tuberculosis (TB) - the world's leading cause of death from a single infectious organism, Mycobacterium tuberculosis - the only vaccine extant has its drawbacks. It was developed early this century
- New veterinary medical science study findings recently were reported by Y....
- Newspaper article from: China Weekly News July 14, 2009 700+ words
...ascertain the relationship to 4/91 vaccine strain. Three field isolates (JP/Wakayama...whereas the identities to the 4/91 vaccine strain and JP/Wakayama-2/2004 were about...foreign field isolates, but not from the vaccine strain. Oil the other hand, the S1 gene...
- Bioterror drill goes awry, lab workers exposed.
- Newspaper article from: Bioterrorism Watch Newsletter April 1, 2008 700+ words
...numerous exposures to an attenuated vaccine strain of Brucella abortus RB51, the Centers...case the specimens were an attenuated vaccine strain of B. abortus used to vaccinate cattle...brucellosis. Human infections with the vaccine strain have been documented in previously...
Source: HighBeam Research, Virulent poliovirus causes paralysis in baby.(Brief Article)