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VSV-based vaccine may protect against papillomavirus.(Brief Article)
2002 SEP 4 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States say that a novel rabbit papillomavirus vaccine prevents infection in animals and could be modified to protect against human forms of the virus.
"Immunizations with live recombinant vesicular stomatitis viruses (rVSV) expressing foreign viral proteins have successfully protected animals from challenges with several heterologous viruses," explained Jon D. Reuter and colleagues at Yale University in New Haven, Connecticut, and the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.
This strategy proved effective against cottontail rabbit papillomavirus (CRPV) as well, and its efficacy could portend a similar vaccine for use with humans, Reuter and coauthors said.
The researchers assessed the performance of a rVSV vector expressing CRPV's major capsid protein L1 (VSV-L1). Study animals were inoculated through skin or muscle injections or with a nasal vaccine spray, according to the report.
Immunized rabbits demonstrated antibody activity against CRPV L1 after a single intradermal or intramuscular injection, or after two intranasal administrations of VSV-L1, study data showed. Complete protection from CRPV infection was seen after intranasal or intramuscular VSV-L1 vaccination with booster doses.
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Source: HighBeam Research, VSV-based vaccine may protect against papillomavirus.(Brief Article)