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Oral antibodies reduce damaging effects of H. pylori infection.(Brief Article)
2002 AUG 21 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Oral delivery of anti-Helicobacter pylori antibodies obtained from chicken egg yolk hindered H. pylori proliferation, according to researchers in Japan.
C. Shimamoto and colleagues at Osaka Medical College, Takatsuki City, Japan, fed inactivated H. pylori to hens, which then produced anti-H. pylori antibodies in the yolks of the eggs they laid. The investigators tested the effects of the purified antibodies in vitro and in vivo in humans and Mongolian gerbils.
Cell culture studies revealed that the anti-H. pylori antibodies could inhibit H. pylori growth significantly, enhance H. pylori agglutination, decrease urease activity, and limited ammonia production. Cultured cells treated with the antibodies resisted cytopathic consequences.
In Mongolian gerbils, the antibodies hindered the production of serum anti-H. pylori immunoglobulin G (IgG) antibodies and reduced the amount of acute gastric inflammation (Inhibition of Helicobacter pylori infection by orally administered yolk-derived anti-Helicobacter pylori antibody. Hepatogastroenterology, 2002;49(45):709-714.)
In humans, oral delivery of the yolk-derived antibodies reduced ...
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Source: HighBeam Research, Oral antibodies reduce damaging effects of H. pylori infection.(Brief...