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Virus-specific cytotoxic T cells found in breast milk.(Brief Article)
2002 AUG 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Mother's milk contains cells that are capable of suppressing HIV infection, researchers in the United States and Africa report.
"Breast-feeding infants of human immunodeficiency virus (HIV)-infected women ingest large amounts of HIV, but most escape infection," explained Steffanie Sabbaj and colleagues working with the University of Alabama at Birmingham, Columbia University in New York City, Boston University, and the Zambia Exclusive Breast-Feeding Study based in Lusaka, Zambia.
HIV-specific cytotoxic T lymphocytes (CTLs) are present in milk from infected mothers, and may help control vertical transmission of the virus, Sabbaj and coauthors found.
The researchers used a gamma-interferon enzyme-linked immunospot assay to investigate antiviral activity in breast milk from 11 HIV+ women. Patients from both the United States and Zambia contributed milk for study, they noted.
Breast milk cells from all 11 women demonstrated immune responses to the HIV Gag peptide, according to the report. Milk cells from most women also responded to Pol and Nef peptides, and some women carried milk that reacted to Env peptides as well.
Further study confirmed that these responses ...
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Source: HighBeam Research, Virus-specific cytotoxic T cells found in breast milk.(Brief Article)