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Invasive pneumococcal disease more prevalent in England/Wales than reported.(Brief Article)
2002 AUG 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The true incidence of invasive pneumococcal disease (IPD) incidence in England and Wales is at least three times the official estimate, according to researchers there.
E.D.G. MacIntosh and R. Booy at Wyeth Vaccines and St. Bartholomew's/Royal London School of Medicine and Dentistry, respectively, in London examined data from the Office for National Statistics (ONS) in England and Wales involving cases of "unspecified" deaths from infectious disease among children younger than 4 years.
The investigators evaluated the tests done to establish cause of infection, and theoretically applied information from modern tests (e.g., polymerase chain reaction, latex agglutination) that are highly sensitive for detection of Streptococcus pneumoniae. Cases of septicemia, meningitis, and pneumonia were examined and the total numbers reduced by 20% to account for nasopharyngeal presence of the pathogens, which the tests might also detect.
In 1989 and 1999, the ONS attributed 13 deaths/year to pneumococcal septicemia, meningitis, or pneumonia. However, the number jumped to at least 43 - more than 3 times the reported number - when information from the more sensitive tests was taken into account using the 1999 data.
MacIntosh and Booy believe the 7-valent pneumococcal conjugate vaccine could prevent as many as 26 (61%) of the IPD-related deaths/year in England and Wales (Invasive pneumococcal ...
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