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Chemotherapy can eliminate the protective effects of measles and rubella immunizations.(Brief Article)
2002 AUG 7 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Children who received intensive chemotherapy for acute lymphoblastic leukemia (ALL) lost their immunity against measles and rubella and required revaccination for these viral diseases, researchers in Sweden and Japan found.
"An increasing number of children survive leukemia as a result of improved and more intense chemotherapy," reported Anna Nilsson and her colleagues in Sweden and Japan. "Survivors of childhood ALL could be at risk for contracting viral infectious diseases and thus could function as a reservoir for additional spread of these viruses in the population."
The investigators evaluated the humoral immunity status of 43 children (13 boys and 30 girls), ages 2 to 12 years, who received chemotherapy for leukemia and had been in remission for an average of 5 years. According to Swedish National immunization program data, all of the children had received measles, mumps, and rubella vaccinations prior to developing leukemia.
Researchers performed enzyme immunoassays to measure the levels of serum antibodies to measles and rubella. The level of measles antibodies was determined also by avidity testing for measles virus IgG. Flow cytometry supplied information on the proportion of plasma cells in the bone marrow (Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens. Pediatrics, 2002;109(6):E91).
Of the 43 children, 26 (60%) possessed immunity against measles and 31 ...
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Source: HighBeam Research, Chemotherapy can eliminate the protective effects of measles and...