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Wide variation in response to toxoplasma antigens found.(Brief Article)
2002 AUG 1 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Researchers in France found that the immune response to toxoplasma antigens varied widely among whole blood cultures from pregnant women infected with the disease.
"The parasite Toxoplasma gondii can infect most mammals and birds, sometimes causing severe pathology," reported A. F. Fatoohi and colleagues working in France. "Primary infection during pregnancy can result in abortion or fetal defects. Host immunity, particularly cellular immunity towards antigenic peptides, can control infection, but an efficient vaccine is not yet available."
The investigators assessed the immune responses of cells from the blood of 22 infected pregnant women and 7 healthy pregnant women. One soluble toxoplasma antigen (ST-Ag) and 5 recombinant antigens (RGRA1,) were tested.
All of the blood samples from the test subjects, but none from the healthy controls, responded to ST-Ag by expressing CD25. Responses to the recombinant antigens, however, varied considerable among the subjects.
Of the 22 samples from the test subjects, 16 (73%) responded to rGRA1. Fewer responses to rSAG1 (13, 59%), rGRA7 (9, 41%), rGRA6-CT (4, 18%), and rGRA6-NT (1, 5%) occurred (Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii, Clinical and Diagnostic Laboratory Immunology, 2002;9(3):704-707).
ST-Ag exposure elicited release of large amounts (4343 [plus-or-minus sign] 2536 pg/mL) of gamma interferon (IFN-gamma). The recombinant antigens induced release of lower levels of ...
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Source: HighBeam Research, Wide variation in response to toxoplasma antigens found.(Brief...