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Alternative hormone treatment shows early promise.(anastrozole (Arimidex) possible breast cancer treatment option)
2002 JUL 25 - (NewsRx.com & NewsRx.net) -- A fast-track study in the June 22, 2002, Lancet suggests that the drug anastrozole could be an effective option for the treatment of postmenopausal women with hormone-sensitive early breast cancer.
Tamoxifen therapy for 5 years after surgery is the established treatment for postmenopausal women with hormone-sensitive breast cancer. However, its use is associated with several side effects, including endometrial cancer and blood-clotting disorders. The ATAC investigators led by Michael Baum from University College London, U.K., and colleagues was an international study that aimed to compare the safety and efficacy of tamoxifen with anastrozole alone and the combination of both drugs for 5 years.
A total of 9366 postmenopausal women from 21 countries who had undergone breast cancer surgery were studied; 3125 were randomly assigned anastrozole, 3116 tamoxifen, and 3125 combination therapy. The average follow-up was just under 3 years (33 months).
Three-year disease-free survival was 2% greater among women given anastrozole (89.4%) compared with those given tamoxifen (87.4%). Combination therapy with both drugs showed no additional benefit compared with women given tamoxifen. Anastrozole was better tolerated than tamoxifen with respect to endometrial cancer, vaginal bleeding and ...
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Source: HighBeam Research, Alternative hormone treatment shows early promise.(anastrozole...