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Isotretinoin has little impact on cervical cancer risk.
2002 JUL 25 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - The retinoid isotretinoin offers little benefit to HIV[superscript]+ women with precancerous cervical lesions, researchers in the United States argue.
William R. Robinson and colleagues at Texas Tech University's Harrington Cancer Center in Amarillo evaluated isotretinoin's ability to prevent low-grade, benign cervical lesions from progressing to high-grade or malignant lesions during HIV infection.
Although the researchers did uncover some good news for HIV[superscript]+ women, they also found that isotretinoin failed to provide them with significant protection from cervical lesion progression.
Female HIV patients with low-grade squamous intraepithelial lesions (SIL) of the cervix were received either 0.5 mg/kg daily doses of isotretinoin or observation for 6 months, according to the report. Usually used to treat severe acne, isotretinoin - like most retinoids - can also be used to help regulate cell growth and differentiation.
However, the risk of developing high-grade cervical SILs was not significantly lower for isotretinoin-treated women than for control patients, with progression rates around 20% in both cohorts, study data showed. Women 30 years of age or younger had significantly higher risk of lesion progression although CD4 cell counts had little or no effect on progression risk.
None of the study ...
- Isotretinoin has little impact on cervical cancer risk.(Brief Article)
- Newspaper article from: AIDS Weekly July 22, 2002 700+ words
...writer - The retinoid isotretinoin offers little benefit...Robinson and colleagues at Texas Tech University's Harrington...Amarillo evaluated isotretinoin's ability to prevent...William R. Robinson, Texas Tech University, Harrington...include: * The retinoid isotretinoin ...
- Isotretinoin in acne vulgaris: a prospective analysis of 160 cases from...
- Magazine article from: Journal of Drugs in Dermatology Al-Mutairi, Nawaf Manchanda, Y. Nour-Eldin, Osama Sultan, Amani May 1, 2005 700+ words
...moderate to severe acne were treated with isotretinoin in the doses ranging from 0.5 mg...period of 12 months after stoppage of isotretinoin for any evidence of relapse. In the...mild acne after 8 weeks of stoppage of isotretinoin therapy, the patients were given another...
- Isotretinoin May Help Pulmonary Symptoms in CF. (CASE REPORT).(cystic fibrosis)
- Magazine article from: Skin & Allergy News Worcester, Sharon November 1, 2001 700+ words
LAKE BUENA VISTA, FLA. -- Isotretinoin could prove to have therapeutic...improved while being treated with isotretinoin (Accutane) for acne. "Intuitively...doxycycline and topical tretinoin. Isotretinoin treatment was then discussed...
- Myths of isotretinoin therapy in patients with acne: a personal opinion.(Focus...
- Magazine article from: Journal of Drugs in Dermatology Alcalay, Joseph March 1, 2004 700+ words
Abstract Isotretinoin therapy for the treatment of severe...associated with acne treatment with isotretinoin. This article expresses the sole...give any guidelines as to the use of isotretinoin. ********** Discussion...
- Facial edema induced by isotretinoin use: a case and a review of the side...
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Abstract Isotretinoin (13-cis-retinoic acid) is a...diseases. For the treatment of acne, isotretinoin is dosed at 0.5 to 2 mg/kg daily...these side effects before taking isotretinoin and also that utilization of moisturizers...
- FDA announces enhancement to isotretinoin risk management program.
- Newspaper article from: Medical Letter on the CDC & FDA December 26, 2004 700+ words
...action plan (RiskMAP) for Accutane (isotretinoin) and its generic equivalents. Isotretinoin is a drug indicated for the treatment...defects associated with fetal exposure to isotretinoin. The strengthened RiskMAP reflects agency...
- Barr Receives Approval for Isotretinoin Capsules USP, 30 mg.
- Press release article from: PR Newswire May 12, 2006 700+ words
...application to manufacture and market Isotretinoin Capsules USP, 30 mg. The Company...Company will now market the full line of Isotretinoin product strengths, including Claravis...compete with Ranbaxy's Sotret(R) (Isotretinoin) Capsules USP, 30 mg that had total...
- Studies seek data on isotretinoin adverse events.(News)
- Magazine article from: Skin & Allergy News Jancin, Bruce April 1, 2006 700+ words
...adverse events associated with the use of isotretinoin for acne--aside from the oral retinoid...support for a causal association between isotretinoin for acne and increased risk of depression...increase in depression scores during isotretinoin therapy when compared with pretreatment...