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Misconceptions about clinical trials and influenza vaccine efficacy widespread among older adults.(Brief Article)
2002 JUL 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Recruiting older adults into a study to assess the cost benefits of influenza vaccination proved difficult because of widely held, but inaccurate, perceptions about the vaccination and about clinical trials, according to researchers in the U.K.
S.J. Allsup and collaborators from the University of Liverpool contacted 6058 older adults who met eligibility requirements for a randomized controlled study on the benefits of influenza vaccination. Only 729 (12%) of those contacted agreed to participate in the study.
The investigators mailed questionnaires to the 2583 (43%) people who declined to join the study. A total of 1173 (45%) of the 2583 people contacted returned questionnaires (Difficulties of recruitment for a randomized controlled trial involving influenza vaccination in healthy older people, Gerontology, 2002;48(3):170-173).
The questionnaires contained 2621 reasons for participation refusal, an average of 2.2 reasons per questionnaire. Misgivings about clinical trial participation was the most common reason for nonparticipation (53%), followed by side effect worries (34%), belief that the vaccination was not personally needed (32%), preference for personal doctor to vaccinate (29%), displeasure at being considered "geriatric" (25%), vaccination already obtained (17%), illness preventing participation (14%), previous adverse ...
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