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Canarypoxvirus-p53 vaccine elicits p53-specific immune response in colorectal cancer patients.(Brief Article)
2002 JUL 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A recombinant canarypoxvirus (ALVAC) expressing human p53 antigen stimulated a specific immune response in patients with advanced colorectal cancer, in a phase I/II study from the Netherlands.
Many types of tumor cells express the p53 antigen, which can elicit a T-cell-mediated immune response. Sjoerd H. van der Burg and colleagues at the Leiden University Medical Center in the Netherlands performed a phase I/II escalation study to determine the effect of a p53 vaccine in patients with colorectal cancer.
The investigators inoculated 15 patients who had advanced colorectal cancer with a recombinant p53-expressing canarypoxvirus (ALVAC) vaccine. The patients were divided into three five-patient groups. Each group received three intravenous inoculations of either one-tenth, one-third, or one dose of the p53 vaccine; one dose being 1x10[superscript]7.5 cell culture infectious dosis (CCID)[subscript]50.
"Potent T-cell and IgG antibody responses against the vector component of the ALVAC vaccine were induced in the majority of the patients," reported van der Burg and associates.
T cell-mediated release of interferon-(gamma) against ALVAC and p53 antigens was found by enzyme-linked immunosorbent-spot assay (ELISPOT). However, no interleukin-4 response was found (Induction of p53-specific immune responses in colorectal cancer patients receiving a ...
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Source: HighBeam Research, Canarypoxvirus-p53 vaccine elicits p53-specific immune response in...