AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine incorporating encapsulated cytokines protects against liver cancer recurrence.(Brief Article)
2002 JUL 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Rearchers in Japan report that a vaccine containing cytokines encapsulated in biodegradable microparticles demonstrated a protective effect against liver cancer in a mouse model and in human clinical trials.
B.G. Peng and colleagues at the Institute of Physical and Chemical Research (RIKEN) in Japan evaluated vaccines to prevent recurrence of hepatocellular carcinoma. The investigators designed a vaccine containing cytokines encased within particles that degrade over time, providing a slow release of the cytokines rather than bolus release. Encapsulated cytokines included granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-2 (IL-2).
In addition to the cytokines, the vaccine consisted of autologous hepatocellular carcinoma cells and tissues fragments and an adjuvant. Studies using a murine model indicated vaccine efficacy. When injected into syngeneic mice, the vaccine protected 33% of the mice against tumor formation after a hepatocellular carcinoma challenge (Autologous fixed tumor vaccine: A formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma, Japanese Journal of Cancer Research, 2002;93(4):363-368).
In phase I and IIa human clinical trials, the vaccine produced a delayed-type hypersensitivity (DTH) response against the tumor cell particles and fragments in 8 of 12 patients who had undergone curative resection ...
- Hepatocellular carcinoma: referral to a specialist centre is recommended.
- Magazine article from: British Medical Journal Ezaki, T. January 25, 1992 700+ words
Worldwide, hepatocellular carcinoma is responsible for...a solitary, small hepatocellular carcinoma in a healthy liver...that in patients with hepatocellular carcinoma the four year survival...
- Liver cell dysplasia and risk of hepatocellular carcinoma in cirrhosis: a...
- Magazine article from: British Medical Journal Borzio, Mauro Bruno, Savino Roncalli, Massimo Mels, Guido Colloredo Ramella, Giorgio Borzio, Franco Leandro, Gioacchino Podda, Mauro June 1, 1991 700+ words
...an increased risk of developing hepatocellular carcinoma. In 1984 we started a long term...independent observers (ES, MR). Hepatocellular carcinoma detected by ultrasound examination...up: none of them had developed hepatocellular carcinoma. Hepatocellular carcinoma ...
- Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in...
- Newspaper article from: Cancer Weekly February 3, 1992 700+ words
...more important risk factor for hepatocellular carcinoma than hepatitis B virus infection...anti-HCV) in patient with hepatocellular carcinoma and in those with cirrhosis of...for cirrhosis-related risk for hepatocellular carcinoma. The first study involved 212...
- Nonviral risk factors for hepatocellular carcinoma in a low-risk population,...
- Newspaper article from: Cancer Weekly January 6, 1992 700+ words
...California School of Medicine. Hepatocellular carcinoma is a rare malignancy among non...established risk factor for hepatocellular carcinoma. In some populations, such as...however, only about half of all hepatocellular carcinoma cases in men and just one third...
- What is the best surveillance for hepatocellular carcinoma in chronic carriers...
- Magazine article from: Journal of Family Practice Rugge, J. Bruin Lochner, Jennifer Judkins, Dolores February 1, 2006 700+ words
...HBsAg+) for hepatocellular carcinoma by alpha-fetoprotein...US) detects hepatocellular carcinoma tumors at earlier...screening for hepatocellular carcinoma has been shown...
- Hepatocellular Carcinoma: Methods and Protocols.(Review)
- Magazine article from: Archives of Pathology & Laboratory Medicine CHEJFEC, GREGORIO May 1, 2001 700+ words
Hepatocellular Carcinoma: Methods and Protocols...Humana Press, 2000. Hepatocellular carcinoma has become one of the most...have a 10% incidence of hepatocellular carcinoma after 20 years. In the...
- Hereditary haemochromatosis and hepatocellular carcinoma in males: a strategy...
- Magazine article from: Journal of Medical Screening Haddow, J.E. Palomaki, G.E. McClain, M. Craig, W. March 22, 2003 700+ words
...study calculated the number of hepatocellular carcinoma cases among a cohort of white...calculate the number of cases of hepatocellular carcinoma that might occur during the lifetime...C282Y homozygotes. Results: Hepatocellular carcinoma was estimated to occur in 2673...
- Peripheral hypereosinophilia in a patient with hepatocellular carcinoma....
- Magazine article from: Southern Medical Journal March 1, 2003 700+ words
...hypereosinophilia associated with hepatocellular carcinoma have been reported...describe a case of hepatocellular carcinoma accompanied by marked...was consistent with hepatocellular carcinoma with areas of cirrhosis...
- Hepatocellular carcinoma regresses spontaneously in some instances.
- Newspaper article from: Drug Week June 18, 2004 700+ words
...com & NewsRx.net) -- Hepatocellular carcinoma regresses spontaneously in some...case of spontaneous regression of hepatocellular carcinoma is reported and compared with...regression of a histologically proven hepatocellular carcinoma was observed in a 42-year...
- Overview of Hepatocellular Carcinoma Provided by New Report.
- Press release article from: M2 Presswire July 18, 2007 700+ words
...Research and Markets: Overview of Hepatocellular Carcinoma Provided by New Report(C)1994...addition of "Stakeholder Opinions: Hepatocellular Carcinoma - Opportune Indication For Novel...association with hepatitis means that hepatocellular carcinoma (HCC) is common in developing...
Source: HighBeam Research, Vaccine incorporating encapsulated cytokines protects against liver...