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Direct plasmid injection with 5-FC administration causes liver tumor regression.(Brief Article)
2002 JUL 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Regression of liver metastases from colon carcinoma resulted from injection of a plasmid expressing the cytosine deaminase gene followed by 5-fluorocytosine in a rat model, researchers in France found.
The cytosine deaminase (CD) gene transforms the nontoxic prodrug, 5-fluorocytosine (5-FC), into 5-fluorouracil (5-FU) which kills cells by disrupting DNA synthesis and triggering apoptosis.
"We previously showed that injection of CD-bearing cancer cells followed by 5-FC treatment can act as an autologous tumor vaccine in a syngenic liver metastasis model in rats," reported P. Baque and associates working at INSERM in Nice.
For the purposes of this study, the investigators used rats with microscopic and macroscopic colon carcinoma metastases in both the right and left liver lobes. Baque and colleagues directly injected a plasmid expressing the CD gene into liver metastases of the left lobe and followed up with 5-FC treatment (Naked DNA injection for liver metastases treatment in rats, Hepatology, 2002;35(5):1144-1152).
Both the microscopic and macroscopic tumors of treated rats receiving the plasmid plus 5-FC experienced significant regression when compared with the tumors of controls (p=0.007 and p
Baque and ...
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Source: HighBeam Research, Direct plasmid injection with 5-FC administration causes liver tumor...