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Study shows promising results for development of preventive vaccine.(Brief Article)
2002 JUL 17 - (NewsRx.com & NewsRx.net) -- The Immune Response Corporation (IMNR) announced results of a study published in the journal Vaccine (2002;20(21-22):2684-2692), which suggested a combination of Remune and immunostimulatory DNA was able to shift the immune response from an antibody mediated response (Th2) to a cell-mediated response (Th1) in mice infected with the parasite Schistosoma.
In the test, mice infected with Schistosoma were immunized with Remune and CpG ODN immunostimulatory DNA and showed significantly lower levels of Th2 related substances and increased levels of Th1 related substances such as the cytokine (gamma) interferon.
According to the published findings, the authors examined "the capacity of a synthetic CpG ODN to induce and/or enhance Th1 immune responses to the coadministered whole killed, gp120-depleted HIV-1 antigen (Remune), in Schistosoma mansoni-infected mice, with a pre-existent dominant Th2 immune profile. Our results showing that a specific Th1 immune response against HIV-1 can be generated in such schistosoma infected mice, following immunization with Remune combined with CpG ODN has prompted this report."
The authors noted that "The relevance and implication of these findings to the situation in the developing world are obvious and very encouraging, especially in view of the difficulty in eradication of parasitic ...
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