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Waiting to vaccinate against hepatitis B may be best policy for preterm infants.(Brief Article)
2002 JUL 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The results of a long-term study that followed preterm infants for several years has revealed that delaying their first hepatitis B virus (HBV) vaccination may work to their advantage.
The study compared two dosing protocols. In the first, preterm infants with low risk factors for hepatitis B virus (HBV) infection were first vaccinated within a day of birth. A control group, comprising infants born at term, also received the vaccine within 24 hours of birth. In the second protocol, infants were only vaccinated when they attained a weight of 2000 g, or a little over 4 pounds. All of the infants subsequently received two more doses of vaccine on standard dosing schedules.
The investigation was performed in Israel, where N. Linder and collaborators working at Schneider Children's Medical Center followed children in all three groups for a little over 3 years before issuing a preliminary report of their data.
According Linder's team, 3 years later, nearly twice as many children born early who received vaccines on a delayed schedule had formed positive antibody to HBV as had children born prematurely who were vaccinated right after birth. The number of antibody-positive children in the delayed-dose group was even higher than in the control group of children born at term who were vaccinated on normal schedules.
Geometric mean concentrations (GMCs), signaling protection against infection, were 119, 14.2, and 32.7 IU/l, ...
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Source: HighBeam Research, Waiting to vaccinate against hepatitis B may be best policy for...