AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Conjugated CD20 vaccine elicits specific, polyclonal immune response in mice.(Brief Article)
2002 JUL 17 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The CD20 antigen, expressed only on B lineage cells before differentiation into plasma cells, produced a strong, specific, polyclonal immune response in mice, researchers in New York have found.
"Monoclonal antibodies to CD20 have been used successfully in the treatment of B-cell lymphomas," explained W.K. Roberts and colleagues at the Memorial Sloan-Kettering Cancer Center in New York City. "Vaccine therapy would have the advantage of generating a polyclonal response to the antigen in contrast to the monoclonal response of an infused antibody."
The investigators inoculated Balb/c mice with a vaccine consisting of human or mouse CD20 peptides conjugated to carrier proteins, and an OS21 adjuvant.
Enzyme-linked immunosorbent assay (ELISA) revealed that inoculation stimulated a high-titer, specific antibody response to several CD20 epitopes. Flow cytometry showed weak antibody binding to native cellular CD20. In some samples, outright death of CD20-expressing cells was caused by antibody-mediated complement. Vaccination with the CD20 antigen also elicited production of interleukin 4 and interferon (gamma).
A 25% decrease in splenic B cells expressing CD19 (compared with control) occurred in mice that received the ...
- Patent No. 7,622,442 Issued on Nov. 24, Assigned to Rockefeller University for...
- News wire article from: US Fed News Service, Including US State News November 25, 2009 700+ words
...Regis Josien, all from New York, and Ralph Steinman...method of modulating immune response in an animal. The inventors...Rockefeller University, New York. According to the abstract...method of modulating immune response in an animal is disclosed...
- The Immune Response Corporation to Present at New York Society of Security...
- Press release article from: PR Newswire December 12, 2006 700+ words
...PRNewswire-FirstCall/ -- The Immune Response Corporation (BULLETIN BOARD...Phase II clinical trials, at the New York Society of Security Analysts...treatment options." About The Immune Response Corporation The Immune Response...
- Publication No. WO/2009/108252 Published on Sept. 3, Assigned to Research...
- News wire article from: US Fed News Service, Including US State News September 11, 2009 700+ words
...developed a method for stimulating immune response against moraxella catarrhalis...Foundation of State University of New York, New York. According to an abstract...stimulating in an individual an immune response against M. catarrhalis. The method...
- Webcast Alert: Immune Response Corporation Announces IMNR Presentation at...
- Press release article from: PR Newswire September 18, 2003 700+ words
Immune Response Corporation announces...Redchip Partners Fall New York Investor Conference...info@imnr.com The Immune Response Corporation is a biopharmaceutical...to induce a specific immune response to the HIV virus. It...
- The Immune Response Corporation to Present at White Mountain Capital Conference...
- Press release article from: Business Wire April 19, 2005 700+ words
...CARLSBAD, Calif. -- The Immune Response Corporation (NASDAQ...Capital Conference held in New York City. President and Chief...presentation. About The Immune Response Corporation The Immune Response Corporation (NASDAQ...
- The Immune Response Corporation to Present at EQUITIES Magazine Transatlantic...
- Press release article from: Business Wire September 13, 2006 700+ words
...Company's New York Presentation to...September 15 The Immune Response Corporation (OTCBB...Stock Exchange, New York City; September...Exchange, Milan. The Immune Response Corporation's...EDT, from the New York City event. In...
- Immune Response Pins Hopes on Study Results.(Brief Article)
- Magazine article from: San Diego Business Journal WEBB, MARION September 10, 2001 700+ words
Officials at Immune Response Corp. said they will...raised concerns whether Immune Response will be able to convince...with Mehta Partners in New York City. "This is a very...to get approved)." Immune Response said Aug. 30 it will...
- The Immune Response Corporation Progress Report at the NYSSA 7th Annual Health...
- Press release article from: PR Newswire November 18, 2003 700+ words
The Immune Response Corporation announced...Eastern time at the New York Society of Security...revitalization that The Immune Response Corporation has achieved...been important for The Immune Response Corporation as we implemented...
Source: HighBeam Research, Conjugated CD20 vaccine elicits specific, polyclonal immune response...