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2002 JUL 17 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The risk of developing complications from cardiac infarction and angioplasty procedures during flu season dropped after influenza vaccination, say investigators in Argentina.
"Recent reports have detected an increase in the number of patients with acute coronary syndromes during the flu season," explained E. P. Gurfinkel and collaborators at the Fundacion Favaloro in Argentina. "We evaluated the preventive impact of vaccination on subsequent ischemic events in myocardial infarction patients and in subjects undergoing planned percutaneous coronary angioplasty."
The investigators conducted a prospective, multicenter trial during the winter months in the Southern Hemisphere. A total of 301 patients, who were either admitted with myocardial infarction (n=200) or who underwent planned angioplasty/stenting (PCI, n=101), participated. Subjects in the PCI group did not have complicating factors such as unstable coronary artery disease (CAD), previous bypass surgery or angioplasty, or tissue necrosis.
After receiving treatment, the infarction patients were randomly assigned to a vaccination or control group, as were the patients in the PCI group. Gurfinkel and associates followed up on the patients at 6 months (Influenza vaccine pilot study in acute coronary syndromes and planned percutaneous coronary interventions: The FLU vaccination acute coronary syndromes (FLUVACS) study, Circulation, 2002;105(18):2143-2147).
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