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Frequently mutated gene identified.(Brief Article)
2002 JUL 11 - (NewsRx.com & NewsRx.net) -- In the June 17, 2002, issue of Nature Genetics, scientists report the identification of a gene that is mutated in 20% (7 out of 35) of primary breast cancers in women.
Approximately 80% of all human cancers are associated with defects in molecular pathways involving a gene called RB1. Curiously, a significant proportion of breast cancers have altered RB1 expression, but no detectable mutation in the gene.
A logical place to look for cancer mutations would therefore be genes that have been implicated in the regulation of the RB1 gene. Tokuhiro Chano and colleagues therefore looked at the RB1CC1 gene. Previous studies had not conclusively shown that it could regulate the RB1 gene, but there was a good deal of evidence to suggest it.
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