Topical solution improves response in women.(topical alprostadil to treat female sexual arousal disorder)(Brief Article)

2002 JUL 11 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Women with female sexual arousal disorder (FSAD) showed increased subjective and objective sexual responses after using topical alprostadil solution, which dilates local blood vessels where applied, according to a new study conducted by Marc Gittelman, MD, medical director of South Florida Medical Research and clinical director of his practice, Uro-medix, in Miami, Florida.

FSAD is a subtype of female sexual dysfunction (FSD), common in women who are postmenopausal.

Seventy-eight women, ages 40 to 70, with FSAD and stable hormonal replacement participated. Half of the group received placebo and the other half received topical alprostadil (100 or 400 [micro sign]g) to apply to the clitoris and surrounding tissues. All women were either postmenopausal or had undergone hysterectomy and bilateral oophorectomy. Patients recorded their sexual responses - genital lubrication, pelvic fullness, pelvic warmth/tingling, level of sexual arousal and level of sexual satisfaction - to explicit videos.

All women who received alprostadil had increased localized blood flow to the vulva and increased genital lubrication - both signs of positive sexual response. There were no reports of significant side effects. There was no difference in ...