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Prophylactic salpingo-oophorectomy reduces risk.(Brief Article)
2002 JUL 11 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - Researchers have shown, for the first time, that women who face an increased risk of breast and ovarian cancer because of mutations in BRCA1 and BRCA2 genes can reduce their risk of these cancers if they have prophylactic salpingo-oophorectomy.
Compared with intensive ovarian screening, surgery to remove the ovaries and fallopian tubes reduced the risk of subsequent breast and ovarian cancers by 75%.
"We now have prospective evidence to present to patients so that they can make informed decisions about their care," said lead investigator Kenneth Offit, MD, chief of the clinical genetics service at Memorial Sloan-Kettering Cancer Center, New York, New York.
The study looked at 173 women whose genetic tests found mutations in the BRCA1 and BRCA2 genes. The women were provided uniform genetic counseling regarding their options. Of those, 101 chose preventive salpingo-oophorectomy. The other 72 opted for intensive ovarian screening (transvaginal ultrasound, and a CA-125 blood test twice a year).
In addition to reducing the risk of ovarian cancer, removing the ovaries is believed to reduce ...
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