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Vasculogenic mimicry in breast cancer a factor for recurrence and lower survival.(Brief Article)
2002 JUL 11 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Building on the work of an earlier study, researchers in Japan have produced evidence supporting of the role of vasculogenic mimicry in breast cancer recurrence and poor survival.
In current breast cancer research, the role of angiogenesis, or the formation of new blood vessels from pre-established ones, has come to the forefront in the study of tumor invasion and metastasis. Now though, Kazuo Shirakawa and colleagues at the National Cancer Research Institute in Tokyo, Japan, are suggesting that vasculogenic mimicry, which resembles angiogenesis but takes a different form, may also be an important factor for recurrence and survival in women with breast cancer.
Shirakawa and coauthors noted that in a previous study, animals engrafted with a human inflammatory breast cancer (IBC) grew tumors that exhibited vasculogenic mimicry, which they characterized as the development of bloodstreams without endothelial cell linings.
In a current study, the team evaluated over 300 breast cancer samples for signs of vasculogenic mimicry by using a variety of analytical methods.
"Surprisingly, 7.9% (26 specimens) of the 331 specimens exhibited evidence of vasculogenic mimicry," reported Shirakawa and investigators.
Pseudo-comedo formation was apparent in slightly more than 80% of the 26 breast cancer samples demonstrating vasculogenic mimicry. Comedo formation in breast cancer is marked by the extrusion of necrotic malignant cells from the ducts.
At least three genes, Tie-2, Flt-1, and thrombin receptor, were significantly expressed in breast cancer samples with vasculogenic mimicry, but ...
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Source: HighBeam Research, Vasculogenic mimicry in breast cancer a factor for recurrence and...