AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Study concludes benefits of anti-HIV therapy during pregnancy outweigh risks.
2002 JUL 9 - (NewsRx.com & NewsRx.net) -- A new study found no association between the use of an anti-HIV treatment that uses a combination of drugs during pregnancy and an increased risk of such birth complications as premature delivery, stillbirth, and low Apgar scores. However, the study did find a slightly increased risk of very low-birth-weight infants (infants weighing less than 1500 g) among women treated with a combination of drugs that included a class of drugs known as protease inhibitors.
The study, a combined analysis of seven studies of U.S. pregnant women with HIV, appears in the June 13, 2002, issue of the New England Journal of Medicine, and was funded by the National Institute of Child Health and Human Development (NICHD) and the National Institute of Allergy and Infectious Diseases (NIAID). The study was conducted by researchers at NICHD, NIAID, and several academic and medical institutions.
The U.S. researchers undertook the study in response to an earlier Swiss study that showed that HIV-positive women who took a combination of anti-HIV drugs that included protease inhibitors were more likely to give birth prematurely than were HIV-positive women who did not take protease inhibitors.
"Combination therapy has proven invaluable in preventing the transmission of HIV from mother to child," said Duane Alexander, MD, director of the NICHD. "This study did not find any association between combination therapy and several adverse pregnancy outcomes. However, a small association between combination therapy with protease inhibitors and very low-birth-weight needs to be investigated further."
Very-low-birth weight infants are at increased risk for infant death and disability. Although they account for only 1% of all births in the United States, they account for more than 40% of infant mortality. Very low-birth-weight infants who do survive often require lengthy and expensive intensive care treatment.
There are three categories of drugs used to treat HIV infection. Reverse transcriptase inhibitors, including the nucleoside and nonnucleoside categories, interfere with an enzyme called reverse transcriptase, which the virus needs to make copies of itself. Protease inhibitors interfere with the enzyme protease, which allows HIV to infect cells. Forms of anti-HIV therapy include giving only one ...
- Protease inhibitors in children: combination therapy reduced death by two...
- Newspaper article from: AIDS Treatment News James, John S. November 23, 2001 700+ words
...accompanying editorial (2) noted that combination therapy with NNRTI drugs can achieve the same...M, Cervia J, and others. Effect of combination therapy including Protease inhibitors on mortality among children and adolescents...
- Clinical efficacy of antiretroviral combination therapy based on protease...
- Magazine article from: British Medical Journal Yazdanpanah, Yazdan Sissoko, Daouda Egger, Matthias Mouton, Yves Zwahlen, Marcel Chene, Genevieve January 31, 2004 700+ words
...antiretroviral regimens based on protease inhibitors and non-nucleoside analogue reverse...Participants had no previous exposure to protease inhibitors or NNRTIs. Data sources Medline...or died. Seven trials assessed protease inhibitors based triple regimens and seven...
- Protease inhibitors: a new weapon and a new strategy against HIV.
- Magazine article from: Journal of the Association of Nurses in AIDS Care Phillips, Kenneth D. September 1, 1996 700+ words
...transcriptase and protease inhibitors, (3) describes...effectiveness of combination therapy strategies...HIV/AIDS, protease inhibitors, reverse...the use of protease inhibitors in combination therapy to treat HIV...
- Bristol-Myers Squibb Acquires New HIV Protease Inhibitors from Novartis
- Press release article from: PR Newswire June 3, 1997 700+ words
...investigate these promising protease inhibitors," said Kenneth...nucleoside analogs with protease inhibitors to achieve greater...role of these new protease inhibitors, focusing on their use in combination therapy with other antiretroviral...
- Cross-resistance analysis of human immunodeficiency virus type 1 variants...
- Newspaper article from: AIDS Weekly Tisdale, M. Myers, R.E. Maschera, B. Parry, N.R. Oliver, N.M. Blair, E.D. September 18, 1995 700+ words
...five different protease inhibitors, have been examined...presence of two protease inhibitors demonstrated...combining different protease inhibitors as well as protease...inhibitors in HIV combination therapy." The corresponding...
- AAG spells bad news for some protease inhibitors. (alpha-1 acid glycoprotein)...
- Newspaper article from: AIDS Weekly DeNoon, Daniel J. February 27, 1995 700+ words
...antiretroviral drugs. Protease inhibitors are designed...is hoped that combination therapy with both types...HIV. Several protease inhibitors are already in...at least some protease inhibitors. The trial...
- Protease inhibitors: good news and bad news. (2nd National Conference on Human...
- Newspaper article from: AIDS Weekly DeNoon, Daniel J. February 27, 1995 700+ words
...several candidate protease inhibitors were announced...binds to some protease inhibitors indicates that...At least 17 protease inhibitors are currently...contribute to combination therapy," Markowitz...
- Protease inhibitors can induce lactic acidosis.
- Newspaper article from: AIDS Weekly March 29, 2004 700+ words
...NewsRx.net) -- HIV protease inhibitors (PIs) can induce lactic...infected patients exposed to combination therapy that includes not only NRTI...nucleoside analogues and protease inhibitors on mitochondrial function...
- Protease inhibitors: early trials promising. (experimental AIDS drugs) (U.S....
- Newspaper article from: AIDS Weekly December 13, 1993 700+ words
Protease inhibitors - a new class of experimental...antiretroviral agents, and protease inhibitors are no exception. "Drug resistance...8959 and AZT monotherapy to combination therapy with the two drugs. Participants...
- New protease inhibitors offer improved clinical effectiveness.
- Newspaper article from: Obesity, Fitness & Wellness Week June 26, 2004 700+ words
...NewsRx.net) -- New protease inhibitors offer improved clinical...and mortality. PI-based combination therapy remains one of several treatment...Deficiency Syndromes (Do new protease inhibitors offer improved clinical...
Source: HighBeam Research, Study concludes benefits of anti-HIV therapy during pregnancy...