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Vaccine reduces recurrent infections in adult women.(Brief Article)
2002 JUL 10 - (NewsRx.com & NewsRx.net) -- by Lynn Yoffee, senior medical writer - A vaccine has shown promise in phase II clinical trials as a possible treatment for recurrent urinary tract infections (UTI) in women.
The vaccine, containing heat-killed uropathogenic bacteria in vaginal suppositories, provokes an immune response that creates resistance to infection, according to a study presented by Walter Hopkins, PhD, from the University of Wisconsin in Madison, at the 97th annual scientific meeting of the American Urological Association (AUA) in Orlando, Florida.
"With the increasing number of drug-resistant bacteria, it is important to develop preventive antibiotic alternatives like this," said Hopkins. "Recurrent urinary tract infections remain a significant problem. This study shows promise and we're planning to institute a third phase of trials in multiple centers."
The phase II trial involved 54 women with recurring UTIs (RUTI) - that is, at least three UTIs in the past year (an average of seven). The women were taken off preventive antibiotics and given a vaginal suppository of vaginal mucosal vaccine to immunize against future infections.
The bacteria that cause infections in the bladder infect mucosal surfaces, thus, the effort to increase immunity at the site which ...
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