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Antibody addition increases success of Streptococcus pneumoniae sepsis treatment.(Brief Article)
2002 JUL 10 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer ? Researchers in Spain report that the presence of specific antibodies lowered the dose of antibiotics needed to successfully treat sepsis caused by Streptococcus pneumoniae in a murine model.
J. Casal and colleagues working at the Carlos III Health Institute in Madrid investigated the impact of specific antibodies on the success of beta-lactam for treatment of non-beta-lactam-susceptible Streptococcus pneumoniae sepsis in BALB/c mice.
The investigators immunized mice with a heat-inactivated strain of S. pneumoniae to obtain hyperimmune serum.
Without addition of hyperimmune serum, untreated mice experienced 100% mortality. However, survival rates of 40% to 60% resulted after one inoculation of hyperimmune serum diluted by one-quarter to one-half (Effects of specific antibodies against Streptococcus pneumoniae on pharmacodynamic parameters of beta-lactams in a mouse sepsis model, Antimicrobial Agents and Chemotherapy, 2002;46(5):1340-1344).
Without hyperimmune serum, a survival rate of 80-100% required 25 mg/kg of body weight of amoxicillin or 50 mg/kg of cefotaxime, a regimen of three inoculations daily for up to six doses. These high doses exceeded the MIC during ...
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Source: HighBeam Research, Antibody addition increases success of Streptococcus pneumoniae...