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Gene for syntenin is overexpressed in metastatic breast and gastric cancers.(Brief Article)
2002 JUL 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers in Korea have identified the gene for a protein that appears to correlate with the spread of some cancers.
The gene for syntenin is overexpressed in certain invasive breast cancer cell lines and upom forced expression in gastric cancer cells, correlates with migration and invasion, scientists report. Therapeutic strategies targeting the syntenin gene might be of benefit for reducing cancer cell dissemination in some individuals.
The syntenin gene stood out as a metastasis candidate when researchers at the Korea Research Institute of Bioscience and Biotechnology identified 17 cDNAs that were differentially expressed in one of two human breast cancer cell lines known for their metastatic potential.
"Expression analysis showed that the expression level of syntenin was well correlated with invasive and metastatic potential in various human breast and gastric cancer cell lines," argued T.H. Koo and colleagues of the Korea Research Institute of Bioscience and Biotechnology in Daejeon, Korea.
Koo and colleagues found that when the cells from the second of the two breast cancer cell lines were transfected with syntenin, they too moved more actively and demonstrated an increased invasion rate (Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines, Oncogene, ...
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Source: HighBeam Research, Gene for syntenin is overexpressed in metastatic breast and gastric...