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Enzyme may compound the spread of breast cancer in women.(Cyclo-oxygenase)(Brief Article)
2002 JUL 4 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cyclo-oxygenase (COX)-2, an enzyme well-known for aggravating arthritis, may also be responsible for facilitating the spread of breast cancers.
That's what researchers have decided after performing exhaustive analyses on the tumors and tissues of 46 patients diagnosed with breast cancers known as invasive ductal breast carcinoma.
The researchers work at several facilities in Porto, Portugal, where they assessed COX-2 expression and its correlation with angiogenesis in breast cancer. Angiogenesis, the growth of new blood vessels, supports metastasis by enabling vascular invasion and facilitating the dissemination of tumor cells to other areas of the body.
Using standard staining techniques, C. Costa and associates, University of Porto, detected COX-2 expression in eight of the breast cancer tumors that they examined. In contrast, COX-2 expression was not evident in normal tissues adjacent to the malignant tumors.
The tumors that expressed COX-2 also harbored a larger number of vessels than did those that did not express COX-2.
Higher levels of the human cancer marker sialyl-Tn, cancer in the lymph nodes, a greater extent of cellular suicide, and shorter disease free survival were linked to COX-2 ...
- COX-2 inhibitors may delay onset.(of breast cancer)
- Newspaper article from: Cancer Weekly November 12, 2002 700+ words
...use of a selective COX (cyclooxygenase...the incidence of breast cancer in HER-2/neu...in the onset of breast cancer in mice, there...potential role for using COX-2 inhibitors to prevent human breast cancer," according to...
- COX-2 inhibitors may delay onset.(breast cancer)
- Magazine article from: Women's Health Weekly November 14, 2002 700+ words
...use of a selective COX (cyclooxygenase...the incidence of breast cancer in HER-2/neu...in the onset of breast cancer in mice, there...potential role for using COX-2 inhibitors to prevent human breast cancer," according to...
- COX-2-derived prostaglandin E-2 is a potent breast cancer stimulant.
- Magazine article from: Women's Health Weekly March 11, 2004 700+ words
...NewsRx.net) -- COX-2-derived prostaglandin E-2 is a potent breast cancer stimulant. "Overexpression...human cyclooxygenase 2 (COX-2) in the mammary...These results define COX-2-derived PGE[subscript...cyclooxygenase 2-induced breast cancer progression. Proc Natl...
- Samoa's Rain Forest Savior - Looking for a cure for breast cancer, Paul Cox...
- Magazine article from: World and I Haapoja, Margaret A. September 1, 2002 700+ words
...Western influences. Here Cox began his research into...of finding a cure for breast cancer, the disease that took...youngest of three children, Cox was especially close...what I could to fight breast cancer," he says. "Then...plant that could help." Cox and his family lived
- GROUP REJECTS DOOM, GLOOM WOMEN WITH BREAST CANCER FIND NEW LIFE
- Newspaper article from: Post-Tribune (IN) October 16, 1988 700+ words
...LINDEMER, SUSAN COX, DOROTHY GILLESPIE - CHART About breast Cancer - To Contact SOURCE...Chesterton resident Susan Cox said, recalling how her own fight with breast cancer began five years...recent meeting. Breast cancer is hardly a topic...approach to life, Cox ...
- Risk assessment added to breast cancer campaign.
- Newspaper article from: Employee Health & Fitness February 1, 2000 700+ words
...health by launching a breast cancer risk assessment program...screenings, notes Sue Cox, RN, occupational...mammography, notes Cox, who says the company...This is not a fad, Cox adds. Everybody talks about [breast cancer screenings] everywhere...
- Fighting breast cancer: The latest diagnostic tools and treatments. (Health...
- Magazine article from: Sarasota Magazine Beiler, Pam January 1, 2002 700+ words
...patients. Dr. Charles E. Cox of the Comprehensive Breast Cancer Program at Moffitt says...to advanced stages of breast cancer, we've seen much...quality of life," Cox says. In the past, most breast cancer patients' lymph nodes...
- Breast cancer survivors scale mountains to raise money. (Originated from...
- Newspaper article from: Knight Ridder/Tribune News Service Anstett, Pat October 21, 1994 700+ words
...is pitch black when Ashley Cox, 22, awakens, grabs her...hates me right now,'' says Cox, a University of Montana junior...January to raise money for breast cancer research. Though many are...the team have in common is breast cancer. Some were diagnosed as recently...
