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Filgrastim is beneficial after stem cell transplantation.(Brief Article)
2002 JUL 4 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Spain say that filgrastim (granulocyte colony-stimulating factor, or G-CSF) treatment can help breast cancer patients recover from hematopoietic stem cell transplantation.
"The administration of G-CSF post-transplant has been shown to accelerate the time to neutrophil engraftment," according to Javier Hornedo and colleagues at the "Twelfth of October" University Hospital in Madrid, Santa Cruz and San Pablo Hospital in Barcelona, and Hospital Clinic of Valencia in Valencia. "However, this does not necessarily translate into a meaningful clinical benefit to the patient."
Hornedo and coauthors showed that G-CSF-enhanced neutrophil engraftment reduces the need for post-transplant hospitalization, thus providing "meaningful clinical benefit," according to their report in the journal Bone Marrow Transplantation.
The researchers evaluated the safety and efficacy of post-transplant G-CSF in 241 breast cancer patients, 200 with high-risk disease and 41 in complete remission. Study participants had already undergone pretransplant G-CSF stem cell mobilization and high-dose STAMP V (cyclophosphamide, carboplatin, and thiotepa) chemotherapy, they noted.
Neutrophil recovery was significantly (p=0.001) more rapid in patients who recieved 5 [micro sign]g/kg of G-CSF ...
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...Posttransplant G-CSF treatment raises the...recipients of matched sibling stem cell grafts. According to...stimulating factor (G-CSF), given after transplantation...Transplantation (G-CSF given after haematopoietic stem cell transplantation using...
- Delayed G-CSF stem cell mobilization after chemotherapy may be feasible.
- Newspaper article from: Health & Medicine Week September 15, 2003 700+ words
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- Vinorelbine-G-CSF cost-effective for stem cell mobilization.
- Newspaper article from: Drug Week April 18, 2003 700+ words
...stimulating factor (G-CSF) is cost-effective for stem cell mobilization in multiple myeloma patients. G-CSF with cyclophosphamide...vinorelbine and G-CSF allow precise timing...Multiple Myeloma and Stem Cell Transplantation. This...
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- Newspaper article from: Cancer Weekly April 15, 2003 700+ words
...stimulating factor (G-CSF) is cost-effective for stem cell mobilization in multiple myeloma patients. G-CSF with cyclophosphamide...vinorelbine and G-CSF allow precise timing...Multiple Myeloma and Stem Cell Transplantation. This...
- Stem cell mobilization feasible with rHu-G-CSF alone for CML patients in...
- Newspaper article from: Hematology Week December 8, 2003 700+ words
...cells using rHu-G-CSF monotherapy is feasible...autologous peripheral blood stem cell transplant (APBSCT...stimulating factor [rHu-G-CSF; 10 microg/kg/d subcutaneously...possible using rHu-G-CSF alone," the researchers...Hematology, Oncology, Stem Cell Transplantation and ...
- CD26 plays role in G-CSF-induced stem cell mobilization.
- Newspaper article from: Drug Week August 15, 2003 700+ words
...periphery as compared with the G-CSF regimen alone." "This suggests...a mechanism of action of G-CSF mobilization involves CD26...peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor...subject areas of Hematology and Stem Cell Research. This article was...
- Postgraft G-CSF impairs immune recovery after mismatched stem cell...
- Newspaper article from: Transplant News April 30, 2001 700+ words
...undergone HLA haplotype-mismatched stem cell transplantation, the administration...colony-stimulating factor (G-CSF) to hasten blood cell reconstitution...43 patients who received G-CSF, although the engraftment rate...Donor cells exposed to G-CSF demonstrated similar immune...
