AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
ATRA helps maintain hemostasis.(all-trans-retinoic acid)(Brief Article)
2002 JUL 4 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - In addition to its anticancer effects, all-trans-retinoic acid (ATRA) can help breast cancer patients maintain hemostasis before surgery, researchers in Italy report.
Dr. Anna Falanga and colleagues at Riuniti Hospital in Bergamo, the University of Genoa and the National Cancer Institute in Genoa, and Roche S.p.A. in Monza performed a study to "evaluate whether all-trans-retinoic acid (ATRA) is able to modulate the hemostatic system in [breast cancer] patients with solid tumors".
ATRA administration reduced the elevated levels of coagulation activity seen during tamoxifen treatment, Falanga and coauthors found.
Patients treated with tamoxifen alone showed increased levels of factor VIIa, thrombin-antithrombin complex, and prothrombin fragment 1+2, they said. While advanced breast cancer patients normally have heightened coagulation activity compared with healthy controls, tamoxifen monotherapy produced significant additional elevations in levels of these hypercoagulation markers.
By contrast, ATRA monotherapy had no effect on coagulation activity. Moreover, ATRA significantly attenuated tamoxifen-induced elevation of hypercoagulability marker levels, study data showed.
Fibrinolysis ...
- hTERT inhibition by Retinoic Acid derivatives in MCF-7 and T47D breast cancer...
- Magazine article from: Journal of the Alabama Academy of Science Wylie, Rebecca C. Hansen, Nathaniel J. Matlock, Jonathan D. Jerkins, James H. Pate, Mitchell S. Andrews, Lucy G. Tollefsbol, Trygve O. April 1, 2003 700+ words
Breast cancer, one of the leading causes of cancer...this study, MCF-7 and T47D human breast cancer cells were treated with therapeutic...animal studies of the treatment of breast cancer, but to this point has yet to be...
- Normal HC11 and ras-transformed mouse mammary cells are resistant retinoic acid.
- Newspaper article from: Biotech Business Week February 9, 2004 700+ words
...NewsRx.net) -- Retinoic acid receptor (RAR) expression...determine the effects of retinoic acid on the growth of the...model for in vitro breast cancer progression. The expression...RARs and RXRs) of retinoic acid receptor mRNAs was...
- Chemical cousin of vitamin A restores gene function in former smokers.(9-cis...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...cells that line the lung. Retinoic acid activates retinoic acid receptors (RARs) that regulate...levels of a key receptor, retinoic acid receptor beta (RAR). Because...to prevent development of breast cancer in lab animals. The third...
- Rambazole: initial results of a new oral retinoic acid metabolism blocking...
- Magazine article from: Journal of Drugs in Dermatology Bergstrom, Kendra G. March 1, 2007 700+ words
...Initial Results of a New Oral Retinoic Acid Metabolism Blocking Agent (RAMBA...Psoriasis Commentary on: Oral retinoic acid metabolism blocking agent Rambazole...context of prostate cancer, breast cancer, and--significantly for dermatology...
- Retinoic acid flunks as a master molecule. (relative of vitamin A doesn't...
- Magazine article from: Science News Ezzel, Carol March 9, 1991 700+ words
Retinoic acid flunks as a master molecule Two reports...implanting microscopic beads coated with retinoic acid into the limb buds of unhatched chicks...Japanese universities -- have shown that retinoic acid, a metabolite of vitamin A, does...
- Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid.
- Press release article from: PR Newswire February 19, 2008 700+ words
...for its lead dermatological product, retinoic acid, a form of vitamin A. This trial...an increase in dermal absorption of retinoic acid when formulated with Phosphagenics...the American Journal of Dermatology, retinoic acid is prescribed most often as the topical...
- Recombinant therapy could sensitize cancer cells to retinoic acid.
- Newspaper article from: Cancer Vaccine Week January 27, 2003 700+ words
...cells could enhance the effectiveness of retinoic acid against certain malignancies. "The response of human cancer cells to retinoic acid (RA) is known to be associated with the expression of retinoic acid receptors (RAR)-beta," said Fuminori...
- Shape-inducing chemical identified. (research on role of retinoic acid in...
- Magazine article from: Science News Weiss, Rick June 27, 1987 700+ words
...a derivative of vitamin A Called retinoic acid. The research reported in the June...programmed growth. The link between retinoic acid levelsand limb differentiation was...mirror-image pattern by implanting retinoic-acid-soaked bits of paper into the front...