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Study suggests that tamoxifen does not adversely impact brain chemistry.(Brief Article)
2002 JUN 27 - (NewsRx.com & NewsRx.net) -- Surprising results from a new study may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, and suggest that both tamoxifen and estrogen have similar effects on the brain.
The study was conducted at Harbor-UCLA Research & Education Institute (REI) in Torrance, California by research collaborators Rowan Chlebowski, MD, PhD, and Thomas Ernst, PhD, and Linda Chang, MD, of Brookhaven National Laboratory in New York. The findings were published in the Journal of the National Cancer Institute and promise to advance breast cancer risk reduction as an achievable medical objective in the near future.
"Based on the increase in hot flashes that are associated with tamoxifen, it has been suggested that the drug blocks the potentially favorable effects of estrogen on the brain. We've found just the opposite," said Chlebowski. "We were surprised to find similarities between the two groups in that women who have been treated with tamoxifen had lower levels of myo-inositol, a chemical that increases in response to brain injury. Women who took estrogen also had lower levels of the ...
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