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High levels of sex hormones doubles risk in postmenopausal women.(Brief Article)
2002 JUN 27 - (NewsRx.com & NewsRx.net) -- Postmenopausal women with relatively high serum concentrations of estrogen and testosterone have about twice the risk of developing breast cancer as women with relatively low serum concentrations of these sex hormones. That is the result of an international study published in the Journal of the National Cancer Institute (2002;93(8)).
The finding was reported by the Endogenous Hormones and Breast Cancer Collaborative Group. Joanne F. Dorgan, MPH, PhD, a member of the Population Science Division at Fox Chase Cancer Center is a lead investigator of one of nine cohorts included in the analysis.
"The overall results show that postmenopausal women with higher serum sex hormone levels including estradiol and testosterone were twice as likely to develop breast cancer," explained Dorgan.
"Associations between serum sex hormone levels and risk of developing breast cancer were not different in women who donated blood closer in time to diagnosis, indicating higher hormone levels in these women were not a preclinical finding."
In each of the nine cohorts included in the analysis, women who donated blood were followed for an average of 2-12 years. During that time 663 women developed breast cancer. Hormones in their blood were compared with the hormones of 1765 women who were the same age when blood was donated as the women who developed breast cancer.
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Source: HighBeam Research, High levels of sex hormones doubles risk in postmenopausal...