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Receptor makes cells more amenable to uptake of virus-mediated gene therapy.(Brief Article)
2002 JUN 27 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The way cells targeted by gene therapies take up viral delivery systems can make or break the effectiveness of the therapy. One way to enhance the sensitivity of ovarian cancer cells to adenovirus-based delivery mechanisms is to increase CAR (coxsackievirus and adenovirus receptor) expression, according to a multicenter Korean study.
"CAR is known to be a primary receptor for attachment during adenovirus infection of target cells and thus is closely related to adenoviral infection efficiency," commented Jong-Sik Kim, an investigator at Sunkyunkwan University in Seoul, Korea.
Kim and colleagues at Kyungpook National University in Taegu, Korea, conducted in vitro analyses of several ovarian cancer cell lines to examine their expression of native CAR and how they reacted to adenovirus infection before and after CAR transfection.
The researchers reported that surface expression of CAR in at least two of the cell lines, 2774 and PA-1, was readily noticeable, and those same two cell lines were highly sensitive to infection by adenoviruses encoding for green fluorescent protein or beta-galactosidase.
Two other cell lines, SKOV3 and OCCAR3, were not as sensitive to adenovirus infection, and they expressed minimal levels of CAR on their surface (Enhancement of the adenoviral sensitivity of human ovarian cancer cells by transient expression of ...
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Source: HighBeam Research, Receptor makes cells more amenable to uptake of virus-mediated gene...