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Macrophage expression of interleukin-8 related to uterine tumor invasion.(Brief Article)
2002 JUN 27 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Physicians in Japan are certain that macrophage-produced interleukin-8 is related to angiogenesis and invasion in uterine endometrial cancer in women.
"Interleukin (IL)-8 is assumed to be a macrophage-derived mediator of angiogenesis," said J. Fujimoto and coauthors, Gifu University, Gifu, Japan. "This prompted us to study the clinical implications of macrophage-derived angiogenesis in uterine endometrial cancer," the team explained in Annals of Oncology.
Upon examining for several growth factors the resected tissues from 68 patients with uterine endometrial carcinoma, microvessel density, and IL-8, Fujimoto and colleagues discovered an interconnectedness between vascularity and IL-8 production that appeared to link both with myometrial invasion.
"There was a significant correlation between microvessel counts and IL-8 levels and between infiltrated macrophage counts and IL-8 levels in uterine endometrial cancers," the team said. Macrophage cells, investigators said, are presumed to supply angiogenic factors to tumors during tumor localization (Clinical implications of expression of interleukin-8 related to myometrial invasion with angiogenesis in uterine endometrial cancers, Annals of Oncology, ...
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...to angiogenesis in uterine endometrial cancers. ... From the tissues of 60 uterine endometrial cancers, the levels...and interleukin (IL)-8 were determined...expression levels in uterine endometrial cancers. Immunohistochemical...
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...to angiogenesis in uterine endometrial cancers. ... From the tissues of 60 uterine endometrial cancers, the levels...and interleukin (IL)-8 were determined...expression levels in uterine endometrial cancers. Immunohistochemical...
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...Novel therapeutic strategy for uterine endometrial cancers,' is newly published data...progression. However, angiogenesis in uterine endometrial cancers is complicated because the...Therefore, angiogenic potential in uterine endometrial cancers must be thoroughly analyzed...
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...responsiveness of normal and carcinogenic uterine endometrial cells to 17b-estradiol (estrogen...normal and cancer cells. In normal uterine endometrial cells, e strogen and estrogen...combinations may be beneficial to normal uterine endometrial cells, they may facilitate ...
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...oligonucleotide (ASODN) on the uterine endometrial cancer Ishikawa cell line. The...oligonucleotide transfection on uterine endometrial cancer Ishikawa cell lines. European...Proteomics, Treatment, Uterine Cancer, Uterine Endometrial Carcinoma, Women's Health. This...
- P2X7 Biomarker Identifies Cancerous and Pre-Cancerous Tissues.
- Press release article from: Business Wire April 12, 2007 700+ words
...that the P2X7 biomarker has the capacity to identify uterine endometrial cancer cells and that P2X7, protein and mRNA assays could potentially be developed to screen for uterine endometrial pre-cancerous (pre-malignant) conditions. Another...
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- Newspaper article from: Diagnostics & Imaging Week Leff, David May 29, 2003 700+ words
...risk. Our research results suggest that just a minimum of seven in 441, or about one in 60, women developed uterine endometrial cancer." He said that all studies of the MSH6 gene show it as part of a Family of DNA repair genes. "This...
Source: HighBeam Research, Macrophage expression of interleukin-8 related to uterine tumor...