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Herpes simplex vectors can enhance immunogenecity.(Brief Article)
2002 JUN 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Herpes simplex-based vectors may be the best choice for antigen delivery by HIV vaccines, researchers report.
"Herpes simplex virus type 1 (HSV-1) infects a wide range of cells, including dendritic cells," explained Dr. Peter K. Hocknell and colleagues working with the University of Rochester Medical Center in Rochester, New York, the University of California-Davis in Davis, California, and the University of Oxford in Oxford, U.K.
Because of this, HSV-1 vectors are highly immunogenic and can help enhance induced antiviral responses to HIV proteins, Hocknell and coauthors found.
The researchers developed a HSV-1 amplicon plasmid coding for the key HIV coat protein gp120. These amplicon particles provoked robust cytotoxic T cell responses in mice at doses as small as 10[superscript]4 infectious units (i.u.), they said.
At higher doses, amplicon plasmids expressing gp120 also triggered powerful antibody responses to the HIV envelope protein Env in study animals. Vaccine-induced humoral and cellular activity was seen nearly 6 months after a single treatment, and could be induced in animals with previous HSV-1 exposure, study data showed.
Intraperitoneal delivery enhanced ...
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