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Statistical model useful for determining prevalence of TB in people with BCG vaccination.(Brief Article)
2002 JUN 26 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - No significant difference existed between the prevalence of tuberculosis (TB) infection in people with a Bacillus Calmette-Guerin (BCG) scar and those without such a scar, say researchers in Switzerland.
BCG is used as a vaccine to prevent tuberculosis where the disease is widespread. However, the vaccine can stimulate the production of antibodies that cause a positive TB skin test, making it difficult to determine whether or not a person is infected with TB.
To determine the prevalence of TB in people both with and without BCG vaccination, B.E. Neuenschwander and colleagues at the Federal Office of Public Health in Berne utilized statistical methods that took into account the differences in indurations caused by tuberculosis, cross-reactions related to mycobacteria infection, and BCG vaccination status. The parameters were allowed to vary by the subjects' sex, age, and presence of BCG vaccination.
The study involved 12,032 people with BCG scars and 7788 people without scars (and so had not been vaccinated with BCG). Similar rates of TB infection were present in both groups of people (Determination of the prevalence of infection with Mycobacterium tuberculosis ...
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Source: HighBeam Research, Statistical model useful for determining prevalence of TB in people...