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Magnesium sulphate halves risk of eclampsia and can save lives of pregnant women.
2002 JUN 20 - (NewsRx.com & NewsRx.net) -- Giving magnesium sulphate injections to pregnant women with preeclampsia halves the risk of eclampsia developing and can save their lives. This is the conclusion of a major international clinical trial funded by the Medical Research Council (MRC) and published in the Lancet.
The 3-year 2.5 million [British] pound study, the Magpie trial, was conducted in 33 countries spanning the U.K. and much of the developing world where eclampsia is the most common cause of death for pregnant women. The trial involved more than 10,000 women who were suffering from preeclampsia.
In addition to normal medical care, half the women in the trial were randomly assigned to receive an injection of magnesium sulphate, an anticonvulsant drug. The other half was allocated a placebo treatment.
Women allocated magnesium sulphate had a 58% lower risk of eclampsia than those allocated the placebo. Although the treatment did not affect whether or not the baby died, there was evidence that it can reduce the risk of the mother dying. A quarter of women reported minor side effects but there was no evidence of harmful effects to either the mother or baby.
Dr. Lelia Duley, an MRC senior clinical fellow and obstetric epidemiologist in the Institute of Health Sciences at the University of Oxford, led the research.
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Source: HighBeam Research, Magnesium sulphate halves risk of eclampsia and can save lives of...