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Metformin curtails gestational onset of diabetes among women with PCOS.(polycystic ovary syndrome (Stein-Leventhal syndrome))(Brief Article)
2002 JUN 13 - (NewsRx.com & NewsRx.net) -- by Roxanne Nelson, staff medical writer - Women with polycystic ovary syndrome (PCOS) can significantly reduce the incidence of gestational diabetes by taking metformin during their pregnancies, say researchers in Ohio.
"In PCOS, use of metformin is associated with a 10-fold reduction in gestational diabetes," reported Charles J. Glueck and his team at the Jewish Hospital in Cincinnati, Ohio.
Utilizing both a prospective and retrospective study, the researchers examined the efficacy and safety of metformin in reducing the onset of gestational diabetes in women with PCOS. In the prospective arm, 33 women with PCOS began taking metaformin before conception, and 28 continued with it up through their delivery date. The retrospective study looked at live births of 39 women with PCOS who did not use metaformin. Both groups excluded women with diabetes, but all of the participants had high fasting insulin and insulin secretion and were insulin resistant.
One of the 33 women (3%) taking metformin developed gestational diabetes during her pregnancy. In contrast, in previous pregnancies among the same group of women, eight out of 12 (67%) had developed gestational diabetes.
In the second group, 14 cases of gestational diabetes were noted in 60 pregnancies (23%). Combining the total number of live births, gestational diabetes was found to develop in 31% of the pregnancies where metaformin was not taken. This is in contrast to 3% of pregnancies where metaformin was utilized (Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ...
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Source: HighBeam Research, Metformin curtails gestational onset of diabetes among women with...