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Ovary removal may prevent cancer.(Brief Article)
2002 JUN 13 - (NewsRx.com & NewsRx.net) -- Women likely to get breast cancer because of a genetic defect may lower their risk substantially by having their ovaries removed, two studies show.
The genes, called BRCA, increase the risk of both breast and ovarian cancer. Doctors often recommend that women with the genes have their ovaries taken out when they reach their 40s, and many also opt to have their breasts removed, too.
The new research raises the possibility that ovary removal alone may be a reasonable option for avoiding both kinds of cancer.
However, while taking out the ovaries lowers a woman's high chance of breast cancer, the operation does not eliminate it, and the decision will depend on how much risk she is willing to live with.
"Prophylactic mastectomy is still the gold standard," said Dr. Kenneth Offit of Memorial Sloan-Kettering Cancer Center in New York City. "Ultimately, these decisions are highly individualized."
Women with the BRCA genes are estimated to have a 50-85% lifetime risk of breast cancer and a 10-40% risk of ovarian cancer.
Offit presented his findings at a meeting in Orlando, Florida of the American Society of Clinical Oncology. His and a similar study by Dr. Timothy Rebbeck of the University of Pennsylvania were published in the May 23, 2002 issue of the New England Journal of Medicine.
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