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2002 JUN 13 - (NewsRx.com & NewsRx.net) -- Estrogen fluctuations may turn on and off genes that control pain and blood vessels, according to results of recent research that sheds new light on the cause of menstrual migraines. These findings may help experts develop more effective treatments for the estimated 6 million American women who have more frequent and intense migraines around the time of periods or during ovulation.
Migraines are headaches characterized by one-sided throbbing pain, nausea, and hypersensitivity to light and noise. They are three times more common among women than men. However, this gender gap is only present in adults; prepubescent girls and boys experience migraines at the same rate. This, combined with the fact that migraines vary with pregnancy and menopause, has pointed the finger at fluctuating female sex hormones.
While the exact cause of migraines remains a mystery, most experts agree that changes in blood flow in and around the brain play an integral role. According to a leading theory, stress, alcohol, hormones or other triggers cause electrical changes in the brain that lead to the opening and inflammation of surrounding blood vessels. Serotonin, a naturally occurring chemical in the brain, seems to be involved in this inflammatory process. The pain and other symptoms of a migraine are thought to arise from alterations in blood flow and inflammation.
Menstrual migraines are often more severe and last longer than other headaches. "Cyclical drops in estrogen are thought to trigger menstrual migraines," said Loretta Mueller, DO, a headache specialist at the University of Medicine and Dentistry of New Jersey in Moorestown, "But exactly how is still not known."
About 20% of migraine sufferers experience a physical warning sign called an aura before a headache sets in. Auras are visual changes such as seeing spots or blurred vision. Increasing evidence suggests that an electrical chain reaction in the brain called cortical spreading depression is the cause of migraine aura.
K. Michael Welch, MD, and colleagues at Kansas University Medical Center in Kansas City examined ...
Source: HighBeam Research, Study offers new insight into menstrual headaches.(Brief Article)