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Meningococcal C conjugates have minimal effect on IgA antibody production.(Brief Article)
2002 JUN 12 - (NewsRx.com & NewsRx.net) -- by Roxanne Nelson, staff medical writer - Researchers in England have found that meningococcal C conjugate vaccines stimulate significant levels of salivary IgG antibodies in infants but have little effect on IgA antibody production.
"Because meningococcus is a mucosal pathogen colonizing the nasopharynx," explained Qibo Zhang, Royal Hospital for Children, and coauthors, "local mucosal immune responses may play an important role in host defense against infection and carriage."
The group investigated IgA and IgG response to two commercially available vaccine products (Menjugate from Chiron Corp, n=46, and Meningitec from Wyeth Lederle, n=54), using saliva samples taken from healthy immunized infants.
The infants received vaccines at 2, 3 and 4 months of age, with saliva sample collection taken immediately prior to the first vaccine and 1 month following the third. A control group of 40 infants followed the same vaccine routine but did not receive the meningococcal C conjugate.
Comparing pre- and postimmunization samples, the researched noted a significant increase in meningococcal C polysaccharide-specific IgG in both groups, postvaccination. No changes were found in the ...
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