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Combination of vaccine and antiviral fractures immune tolerance in virus model.(Brief Article)
2002 JUN 12 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Woodchuck hepatitis virus (WHV) infects woodchucks in a manner similar to the way hepatitis B virus (HBV) infects humans. Using woodchucks infected with WHV, U.S. investigators have shown how combining an antiviral with surface antigen vaccination can break humoral and cell-mediated immune tolerance in infected animals.
For the study, research collaborators at Cornell University in Ithaca, New York, and at the Georgetown University Medical Center facility in Rockville, Maryland, first treated several WHV-infected woodchucks with 1-(2-fluoro-5-methyl-Beta-L-arabinofuranosyl)-uracil (L-FMAU), an antiviral agent, for 8 months. Several other infected animals received placebo.
The investigators then inoculated several animals from both groups with four injections of WHV vaccine containing surface antigen during the following 4 months.
"Vaccination alone elicited a low-level antibody response to surface antigen in most carriers but did not affect serum WHV DNA and surface antigen," reported Stephan Menne of the Department of Clinical Sciences at Cornell. Similar antibody response was observed in animals pretreated with the antiviral, the team noted.
Both sets of animals exhibited cell-mediated immunity to surface antigen following the vaccinations, but the effect of vaccination was more extensive in animals that had received L-FMAU, as investigators identified response to viral antigens other than just surface antigen (Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-Beta-L-arabinofuranosyl)-uracil ...
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Source: HighBeam Research, Combination of vaccine and antiviral fractures immune tolerance in...